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Science 21 July 1978:
Vol. 201. no. 4352, pp. 272 - 274
DOI: 10.1126/science.351807
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Articles

Science, Vol 201, Issue 4352, 272-274
Copyright © 1978 by American Association for the Advancement of Science

articles

Physostigmine: improvement of long-term memory processes in normal humans

KL Davis, RC Mohs, Tinklenberg JR, A Pfefferbaum, LE Hollister, and BS Kopell

Nineteen normal male subjects received 1.0 milligram of physostigmine or 1.0 milligram of saline by a slow intravenous infusion on two nonconsecutive days. Physostigmine significantly enhanced storage of information into long-term memory. Retrieval of information from long-term memory was also improved. Short-term memory processes were not significantly altered by physostigmine.


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