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Science 21 July 1978:
Vol. 201. no. 4352, pp. 267 - 269
DOI: 10.1126/science.663655
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Articles

Science, Vol 201, Issue 4352, 267-269
Copyright © 1978 by American Association for the Advancement of Science

articles

Chronically decerebrate rats demonstrate satiation but not bait shyness

HJ Grill and R Norgren

Taste substances applied to the oral cavity result in either ingestion or rejection, each with a characteristic muscular response pattern. These responses are the same in decerebrate and intact rats; the caudal brainstem appears to be the neural substrate of ingestion and rejection responses. The experiment determined whether decerebrates can alter these discriminative responses as a function of food deprivation or toxicosis. Food-deprived decerebrate rats, like intact ones, ingested a taste substance they had rejected when sated. However, these same decerebrates, in contrast to controls, neither rejected nor decreased ingestive reactions to a novel taste after that taste had been repeatedly paired with lithium chloride-induced illness. Although the forebrain may be important for integrating ingestion, some aspects of this control seem to be represented in caudal brain areas.


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Fos-like immunoreactivity in the brain stem following oral quinine stimulation in decerebrate rats.
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