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Science 21 July 1978:
Vol. 201. no. 4352, pp. 255 - 257
DOI: 10.1126/science.208149
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Articles

Science, Vol 201, Issue 4352, 255-257
Copyright © 1978 by American Association for the Advancement of Science

articles

Pressure-adaptive differences in lactate dehydrogenases of congeneric fishes living at different depths

J Siebenaller and GN Somero

The muscle-type (M4) lactate dehydrogenases of Sebastolobus altivelis, a deep-water scorpaenid, and S. alascanus, a shallower species, are electrophoretically indistinguishable, yet differ in pressure sensitivities. The lactate dehydrogenase of S. altivelis exhibits lower pressure sensitivities of substrate and coenzyme binding and catalytic rate. Such apparently pressure-adaptive kinetic properties may be important for establishing species depth zonation patterns in the ocean.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Trimethylamine oxide stabilizes teleost and mammalian lactate dehydrogenases against inactivation by hydrostatic pressure and trypsinolysis.
P. Yancey and J. Siebenaller (1999)
J. Exp. Biol. 202, 3597-3603
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