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Science 14 July 1978:
Vol. 201. no. 4351, pp. 171 - 173
DOI: 10.1126/science.566468
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Articles

Science, Vol 201, Issue 4351, 171-173
Copyright © 1978 by American Association for the Advancement of Science

articles

Long-term treatment with lithium prevents the development of dopamine receptor supersensitivity

A Pert, JE Rosenblatt, C Sivit, CB Pert, and WE Bunney Jr

Long-term treatment of rats with haloperidol produced an increased sensitivity to the locomotor and stereotypic effect of apomorphine. This behavioral dopaminergic supersensitivity was accompanied by increased binding of [3H] spiroperidol in the striatum. Rats treated concurrently with lithium and haloperidol failed to develop both behavioral sensitivity to apomorphine and increased striatal dopamine receptor binding. The ability of lighium to prevent recurrent manicdepressive episodes may be related, in part, to its ability to stabilize dopaminergic receptor sensitivity.


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