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Science 14 July 1978:
Vol. 201. no. 4351, pp. 155 - 157
DOI: 10.1126/science.208147
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Articles

Science, Vol 201, Issue 4351, 155-157
Copyright © 1978 by American Association for the Advancement of Science

articles

Rise and fall of cyclic AMP required for onset of lymphocyte DNA synthesis

T Wang, Sheppard JR, and JE Foker

The adenosine 3',5'-monophosphate (cyclic AMP) levels of mouse lymphocytes rose and fell sharply 10 hours after stimulation with concanavalin A. Treatment of the cells with indomethacin reversibly prevented the increase in cyclic AMP and the subsequent onset of DNA synthesis. When the heightened cyclic AMP before S phase was maintained by either inhibiting phosphodiesterase or by adding the 8-bromo derivative of cyclic AMP, DNA synthesis was also blocked. Both the increase and decrease in cyclic AMP appear to be required for progression of lymphocytes into the S phase of growth.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inhibition of T-Cell Receptor Signal Transduction and Viral Expression by the Linker for Activation of T Cells-Interacting p12I Protein of Human T-Cell Leukemia/Lymphoma Virus Type 1.
R. Fukumoto, M. Dundr, C. Nicot, A. Adams, V. W. Valeri, L. E. Samelson, and G. Franchini (2007)
J. Virol. 81, 9088-9099
   Abstract »    Full Text »    PDF »
Direct evidence that endogenous GM1 ganglioside can mediate thymocyte proliferation.
S Spiegel, P. Fishman, and R. Weber (1985)
Science 230, 1285-1287
   Abstract »    PDF »


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