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Science 7 July 1978:
Vol. 201. no. 4350, pp. 69 - 71
DOI: 10.1126/science.26974
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Articles

Science, Vol 201, Issue 4350, 69-71
Copyright © 1978 by American Association for the Advancement of Science

articles

Histamine H1 receptor-mediated guanosine 3',5'-monophosphate formation by cultured mouse neuroblastoma cells

E Richelson

Incubation of cultured mouse neuroblastoma cells with histamine caused a rapid and marked increase in the formation of guanosine 3',5'-monophosphate (cyclic GMP) by these cells. Receptor agonists for H1, but not H2, caused this effect which was reduced by H1 but not by H2 or muscarinic acetylcholine receptor antagonists. These results indicate that activation of H1 receptors in these cultured nerve cells stimulated cyclic GMP formation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Thrombin stimulation of guanosine 3',5'-monophosphate formation in murine neuroblastoma cells (clone N1E-115).
R. Snider and E Richelson (1983)
Science 221, 566-568
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