Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 7 July 1978:
Vol. 201. no. 4350, pp. 65 - 67
DOI: 10.1126/science.663638
Prev | Table of Contents | Next

Articles

Science, Vol 201, Issue 4350, 65-67
Copyright © 1978 by American Association for the Advancement of Science

articles

6-Mercaptopurine treatment of pregnant mice: effects on second and third generations

TJ Reimers and PM Sluss

The immunosuppressive drug 6-mercaptopurine is embryotoxic in mice. Of the surviving female offspring of mice treated with low doses of 6-mercaptopurine during pregnancy, despite normal body weight and general appearance, many were either sterile or, if they became pregnant, had smaller litters and more dead fetuses as compared to offspring of mothers that had not received the drug.




To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)