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Science 30 June 1978:
Vol. 200. no. 4349, pp. 1496 - 1497
DOI: 10.1126/science.663632
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Articles

Science, Vol 200, Issue 4349, 1496-1497
Copyright © 1978 by American Association for the Advancement of Science

articles

Cystic fibrosis: decreased conjugation and excretion of [14C]spermidine

MG Rosenblum, BG Durie, RC Beckerman, LM Taussig, and DH Russell

Free and conjugated [14C]spermidine were measured in plasma samples from normal individuals and cystic fibrosis patients. Within 4 minutes, the 14C-labeled material in the plasma from normal individuals was 70 percent conjugated compared to no detectable conjugation by cystic fibrosis patients. Further, the patients excreted only 11 to 13 percent of the [14C]spermidine in their urine within 72 hours whereas normal excretion was 60 to 76 percent. In both cases, the labeled material was in a conjugated form.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target.
M. C. Bewley, V. Graziano, J. Jiang, E. Matz, F. W. Studier, A. E. Pegg, C. S. Coleman, and J. M. Flanagan (2006)
PNAS 103, 2063-2068
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Science. ISSN 0036-8075 (print), 1095-9203 (online)