Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 30 June 1978:
Vol. 200. no. 4349, pp. 1487 - 1489
DOI: 10.1126/science.663630
Prev | Table of Contents | Next

Articles

Science, Vol 200, Issue 4349, 1487-1489
Copyright © 1978 by American Association for the Advancement of Science

articles

Nitrite and nitrate are formed by endogenous synthesis in the human intestine

Tannenbaum SR, D Fett, VR Young, PD Land, and WR Bruce

Studies of nitrate balance in humans and analyses of fecal and ileostomy samples indicate that nitrite and nitrate are formed de novo in the intestine, possibly by heterotrophic nitrification. These findings significantly alter our previous conceptions of human exposure to nitrite and suggest an even wider role for nitrite in the etiology of human cancer.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Consumption of cured meats and risk of chronic obstructive pulmonary disease.
C. K. Chow (2008)
Am. J. Clinical Nutrition 88, 1703
   Full Text »    PDF »
Recovery of 15N in the Body, Urine, and Gas Phase of Piglets Infused Intravenously with 15N L-Alanine from 12-72 Hours of Age.
T. W. Rasch and N. J. Benevenga (2004)
J. Nutr. 134, 847-854
   Abstract »    Full Text »    PDF »
Nitric oxide synthesis in patients with infective gastroenteritis.
P Forte, R S Dykhuizen, E Milne, A McKenzie, C C Smith, and N Benjamin (1999)
Gut 45, 355-361
   Abstract »    Full Text »    PDF »
Gut reactions of radioactive nitrite after intratracheal administration in mice.
Thayer JR, J. Chasko, L. Swartz, and N. Parks (1982)
Science 217, 151-153
   Abstract »    PDF »
Fermentation in the rumen and human large intestine.
M. Wolin (1981)
Science 213, 1463-1468
   Abstract »    PDF »
Evaluation of nitrate synthesis by intestinal microorganisms in vivo.
J. Witter, S. Gatley, and E Balish (1981)
Science 213, 449-450
   Abstract »    PDF »
Nitrate synthesis in the germfree and conventional rat.
L. Green, Tannenbaum SR, and P Goldman (1981)
Science 212, 56-58
   Abstract »    PDF »
Nitrogen-13-labeled nitrite and nitrate: distribution and metabolism after intratracheal administration.
N. Parks, K. Krohn, C. Mathis, J. Chasko, K. Geiger, M. Gregor, and N. Peek (1981)
Science 212, 58-60
   Abstract »    PDF »
Role of nitrogen dioxide in the biosynthesis of nitraosamines in mice.
Z. Iqbal, K Dahl, and S. Epstein (1980)
Science 207, 1475-1477
   Abstract »    PDF »
Nitrate and Nitrite: Origin in Humans.
J. P. WITTER, S. J. GATLEY, and E. BALISH (1979)
Science 205, 1335-1337
   PDF »
Nitrite promotes lymphoma incidence in rats.
P. Newberne (1979)
Science 204, 1079-1081
   Abstract »    PDF »
Distribution of nitrogen-13 from labeled nitrate (13No3-) in humans and rats.
J. Witter, S. Gatley, and E Balish (1979)
Science 204, 411-413
   Abstract »    PDF »
Nutrition: A Medical, Political, and Public Issue.
(1979)
JAMA 241, 1407-1408
   Abstract »    PDF »
Carcinogens in Food and the Delaney Clause.
T. H. Jukes (1979)
JAMA 241, 617-619
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)