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Science 23 June 1978:
Vol. 200. no. 4348, pp. 1397 - 1398
DOI: 10.1126/science.351801
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Articles

Science, Vol 200, Issue 4348, 1397-1398
Copyright © 1978 by American Association for the Advancement of Science

articles

Chloroquine resistance produced in vitro in an African strain of human malaria

P Nguyen-Dinh and W Trager

After condinous cultivation in the presence of chloroquine, an African strain of the malaria parasite, Plasmodium falciparu, acquired resistance to the drug. The resistance was stable and comparable in vitro to that occurring naturally in a strain from Southeast Asia. This suggests that chloroquine resistance, absent until now in Africa, might arise in the future.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)