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Science 23 June 1978:
Vol. 200. no. 4348, pp. 1393 - 1395
DOI: 10.1126/science.307275
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Articles

Science, Vol 200, Issue 4348, 1393-1395
Copyright © 1978 by American Association for the Advancement of Science

articles

Isolated retinas synthesize visual pigments from tetinol congeners delivered by liposomes

S Uoshikami and GN Noll

Isolated vertebrate retinas bathed in circulating Ringer solution cannot regenerate all of their bleached visual pigments. When dioleoyl-lecithin vesicles containing certain retinol congeners are added to the Ringer solution, such retinas begin to regenerate pigment immediately. The visual pigment of a bleached perfused retina can now be restored fully, making the isolated retina an independent unit for study. Loposomes can protect oxygen-sensitive, lipid-soluble substances and deliver them to living cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Biochemistry of Visual Pigment Regeneration The Friedenwald Lecture.
J. C. Saari (2000)
Invest. Ophthalmol. Vis. Sci. 41, 337-348
   Full Text »
Interaction of 11-cis-Retinol Dehydrogenase with the Chromophore of Retinal G Protein-coupled Receptor Opsin.
P. Chen, T. D. Lee, and H. K. W. Fong (2001)
J. Biol. Chem. 276, 21098-21104
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)