Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
BioJapan 2008

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 16 June 1978:
Vol. 200. no. 4347, pp. 1303 - 1304
DOI: 10.1126/science.663614
Prev | Table of Contents

Articles

Science, Vol 200, Issue 4347, 1303-1304
Copyright © 1978 by American Association for the Advancement of Science

articles

Genetic method for the preferential elimination of females of anopheles albimanus

JA Seawright, PE Kaiser, DA Dame, and CS Lofgren

Recent field experiments demonstrated the possibility of using the sterile male method for the control of Anopheles albimanus Wiedemann, the most important vector of human malaria in Central America. Until now there was no practical method for excluding females from the releases of sterile males. A genetic method was developed for the preferential elimination of females during any of the four life stages. This genetic sexing system utilizes propoxur (o-isopropoxyphenyl methyl-carbamate) susceptibility as a recessive conditional lethal a T(Y:2R) translocation, and an In(2R)inversion. The propoxur resistance allele (dominant) was linked to the Y chromosome via a radiation-induced translocation, and genetic recombination was suppressed by inversions. In one of the strains produced, 99.7 percent of the females are eliminated when treated with propoxur, without male loss.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Analyzing the control of mosquito-borne diseases by a dominant lethal genetic system.
M. P. Atkinson, Z. Su, N. Alphey, L. S. Alphey, P. G. Coleman, and L. M. Wein (2007)
PNAS 104, 9540-9545
   Abstract »    Full Text »    PDF »
Towards genetic manipulation of wild mosquito populations to combat malaria: advances and challenges.
M. A. Riehle, P. Srinivasan, C. K. Moreira, and M. Jacobs-Lorena (2003)
J. Exp. Biol. 206, 3809-3816
   Abstract »    Full Text »    PDF »
Insect Population Control Using a Dominant, Repressible, Lethal Genetic System.
D. D. Thomas, C. A. Donnelly, R. J. Wood, and L. S. Alphey (2000)
Science 287, 2474-2476
   Abstract »    Full Text »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)