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Science 16 June 1978:
Vol. 200. no. 4347, pp. 1285 - 1287
DOI: 10.1126/science.663610
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Articles

Science, Vol 200, Issue 4347, 1285-1287
Copyright © 1978 by American Association for the Advancement of Science

articles

Effect of myasthenic immunoglobulin on acetylcholine receptors of intact mammalian neuromuscular junctions

EF Stanley and DB Drachman

Degradation of acetylcholine receptors of intact mouse neuromuscular junctions was determined in vivo and in vitro by the release of radioactivity from mouse diaphragms labeled with 125I-alpha-bungarotoxin. Treatment of mice with immunoglobulin from myasthenic patients accelerated the degradation rate to approximately three times normal, in both intact animals and organ cultures. The released radioactivity was in the form of [125I]tyrosine, confirming the nature of the degradative process. Accelerated degradation of acetylcholine receptors at neuromuscular junctions may represent an important antibody-mediated mechanisms in myasthenia gravis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Continuous Neostigmine Infusion in Post-Thymectomy Juvenile Myasthenic Crisis.
G. Briassoulis, T. Hatzis, T. Liakopoulou, and S. Youroukos (2000)
J Child Neurol 15, 747-749
   Abstract »    PDF »
The Th2 Cytokine IL-4 Is Not Required for the Progression of Antibody-Dependent Autoimmune Myasthenia Gravis.
B. Balasa, C. Deng, J. Lee, P. Christadoss, and N. Sarvetnick (1998)
J. Immunol. 161, 2856-2862
   Abstract »    Full Text »    PDF »
Interferon gamma  (IFN-gamma ) Is Necessary for the Genesis of Acetylcholine Receptor-induced Clinical Experimental Autoimmune Myasthenia gravis in Mice.
B. Balasa, C. Deng, J. Lee, L. M. Bradley, D. K. Dalton, P. Christadoss, and N. Sarvetnick (1997)
J. Exp. Med. 186, 385-391
   Abstract »    Full Text »    PDF »
Myasthenia Gravis.
D. B. Drachman (1994)
N. Engl. J. Med. 330, 1797-1810
   Full Text »
Rapid degradation of "new" acetylcholine receptors at neuromuscular junctions.
E. Stanley and D. Drachman (1983)
Science 222, 67-69
   Abstract »    PDF »


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