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Science 16 June 1978:
Vol. 200. no. 4347, pp. 1281 - 1283
DOI: 10.1126/science.663608
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Articles

Science, Vol 200, Issue 4347, 1281-1283
Copyright © 1978 by American Association for the Advancement of Science

articles

Thrombin-induced platelet aggregation is mediated by a platelet plasma membrane-bound lectin

TK Gartner, DC Williams, FC Minion, and DR Phillips

Throbin-activated human platelets cause agglutination of trypsinized, formalinized bovine erythrocytes. This lectin activity of stimulated platelets was blocked by galactosamine, glucosamine, mannosamine, lysine, and arginine, but not by N-acetylated sugars, other neutral sugars, or other amino acids. Inhibitors of the thrombin-induced lectin activity also blocked thrombin-induced platelet aggregation. It appears that a membrane surface component that has lectin activity mediates platelet aggregation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
P-Selectin Expression on Platelets Determines Size and Stability of Platelet Aggregates.
M. Merten and P. Thiagarajan (2000)
Circulation 102, 1931-1936
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