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Science 16 June 1978:
Vol. 200. no. 4347, pp. 1270 - 1272
DOI: 10.1126/science.96524
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Articles

Science, Vol 200, Issue 4347, 1270-1272
Copyright © 1978 by American Association for the Advancement of Science

articles

Excitation-contraction coupling in skeletal muscle: blockade by high extracellular concentrations of calcium buffers

N Barrett and EF Barrett

High concentrations (80 to 90 millimolar) of the calcium buffers EGTA and citrate (less than 10(-7) molar free calcium ion) reversibly block excitation-contraction coupling in intact frog skeletal fibers, but do not block caffeine-induced contractures. Solutions containing the same free calcium concentration but lower concentrations of calcium buffer (1 millimolar) do not block excitation-contraction coupling. These results suggest that excitation-contraction coupling requires the presence of calcium in a "protected" extracellular compartment, probably the transverse tubular network, and that calcium is actively transported into this compartment from the muscle cell cytoplasm.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Enhanced Excitation-coupled Calcium Entry in Myotubes Is Associated with Expression of RyR1 Malignant Hyperthermia Mutations.
T. Yang, P. D. Allen, I. N. Pessah, and J. R. Lopez (2007)
J. Biol. Chem. 282, 37471-37478
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Science. ISSN 0036-8075 (print), 1095-9203 (online)