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Science 9 June 1978:
Vol. 200. no. 4346, pp. 1180 - 1182
DOI: 10.1126/science.206967
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Articles

Science, Vol 200, Issue 4346, 1180-1182
Copyright © 1978 by American Association for the Advancement of Science

articles

Adrenocorticotropin in rat brain: immunocytochemical localization in cells and axons

SJ Watson, CW Richard 3rd, and JD Barchas

By means of antiserum (purified by affinity chromatography) directed against adrenocorticotropin (ACTH) 11-24, cell bodies and beaded axons were visualized in rat brain. The ACTH-like immunoreactivity (ACTH-LI) was primarily located in the hypothalamus (cells and axons). Fibers were scattered throughout thalamus, amygdala, periaqueductal gray area, and reticular formation. There was no change in the distribution of ACTH-LI in rats that had been subjected to hypophysectomy. This distribution of ACTH-LI parallels that of beta-lipotropin and is altered by specific lesions in a similar fashion. The presence of ACTH-LI in cells and beaded axons in brain raises the possibility that it is a neuroregulator functioning as a neurotransmitter, neuromodulator, or neurohormone.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Some Observations on the Opiate Peptides and Schizophrenia.
S. J. Watson, H. Akil, P. A. Berger, and J. D. Barchas (1979)
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Opiate effects after adrenocorticotropin or beta-endorphin injection in the periaqueductal gray matter of rats.
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Anatomy of an Endogenous Antagonist: Relationship between Agouti-Related Protein and Proopiomelanocortin in Brain.
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