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Science 9 June 1978:
Vol. 200. no. 4346, pp. 1177 - 1178
DOI: 10.1126/science.653363
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Articles

Science, Vol 200, Issue 4346, 1177-1178
Copyright © 1978 by American Association for the Advancement of Science

articles

Receptors for glucocorticoids in the lens epithelium of the calf

AL Southren, GG Gordon, HS Yeh, MW Dunn, and BI Weinstein

The calf lens epithelium contains a specific cytoplasmic receptor for glucocorticoids. This binding protein has a high affinity for dexamethasone (average dissociation constant, 8 x 10(-9) mole per liter), a low capacity (average, 550 femtomoles per milligram of protein), extreme heat sensitivity, and exhibits a pattern of competition similar to that of glucocorticoid receptors in other tissues. This provides direct biochemical evidence that these tissues may function as a target organ for glucocorticoids.


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