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Science 9 June 1978:
Vol. 200. no. 4346, pp. 1173 - 1175
DOI: 10.1126/science.418505
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Articles

Science, Vol 200, Issue 4346, 1173-1175
Copyright © 1978 by American Association for the Advancement of Science

articles

Potent antidopaminergic activity of estradiol at the pituitary level on prolactin release

V Raymond, M Beaulieu, F Labrie, and J Boissier

Prior incubation of rat anterior pituitary cells with 17beta-estradiol led to an almost complete reversal of the inhibitory effect of two dopamine agonists, dihydroergocornine and RU 24213, on both basal prolactin release and thyrotropin releasing hormone-induced prolactin release. These experiments thus demonstrate a direct interference of dopamine action by a peripheral hormone. Prolactin secretion by pituitary cells in primary culture could possibly serve as an easily accessible model of a system under dopaminergic control.


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Prospective Study of High-Dose Cabergoline Treatment of Prolactinomas in 150 Patients.
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J Psychopharmacol 22, 12-19
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Estrogen Actions on Lactotroph Proliferation Are Independent of a Paracrine Interaction with Other Pituitary Cell Types: A Study Using Lactotroph-Enriched Cells.
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Reproductive Experience Reduces Circulating 17{beta}-Estradiol and Prolactin Levels during Proestrus and Alters Estrogen Sensitivity in Female Rats.
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Effects of long-term treatment with resveratrol and subcutaneous and oral estradiol administration on pituitary function in rats..
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Expression of Estrogen Receptor Subtypes in Rat Pituitary Gland during Pregnancy and Lactation.
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Prolactin: Structure, Function, and Regulation of Secretion.
M. E. Freeman, B. Kanyicska, A. Lerant, and G. Nagy (2000)
Physiol Rev 80, 1523-1631
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Stage- and Region-Specific Expression of Estrogen Receptor {alpha} Isoforms during Ontogeny of the Pituitary Gland.
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Effects of hormone replacement on growth hormone and prolactin exercise responses in postmenopausal women.
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R. A. Sweet, M. Akil, B. H. Mulsant, R. Ulrich, R. E. Pasternak, and G. S. Zubenko (1998)
J Neuropsychiatry Clin Neurosci 10, 68-77
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Role of Estrogen Receptor-{{alpha}} in the Anterior Pituitary Gland.
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Mol. Endocrinol. 11, 674-681
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Sex Difference in Age at Onset of Schizophrenia.
A. W. Loranger (1984)
Arch Gen Psychiatry 41, 157-161
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Damage to hypothalamic dopaminergic neurons is associated with development of prolactin-secreting pituitary tumors.
D. Sarkar, P. Gottschall, and J Meites (1982)
Science 218, 684-686
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Tardive Dyskinesia: Prevalence and Risk Factors, 1959 to 1979.
J. M. Kane and J. M. Smith (1982)
Arch Gen Psychiatry 39, 473-481
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Calcium spike electrogenesis and other electrical activity in continuously cultured small cell carcinoma of the lung.
F. McCann, O. Pettengill, J. Cole, J. Russell, and G. Sorenson (1981)
Science 212, 1155-1157
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Bromocriptine and Pituitary Disorders.
J. KELLETT and H. G. FRIESEN (1979)
Ann Intern Med 90, 980-982
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Opioid peptides modulate luteinizing hormone secretion during sexual maturation.
M. Blank, A. Panerai, and H. Friesen (1979)
Science 203, 1129-1131
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