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Science 9 June 1978:
Vol. 200. no. 4346, pp. 1173 - 1175
DOI: 10.1126/science.418505
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Articles

Science, Vol 200, Issue 4346, 1173-1175
Copyright © 1978 by American Association for the Advancement of Science

articles

Potent antidopaminergic activity of estradiol at the pituitary level on prolactin release

V Raymond, M Beaulieu, F Labrie, and J Boissier

Prior incubation of rat anterior pituitary cells with 17beta-estradiol led to an almost complete reversal of the inhibitory effect of two dopamine agonists, dihydroergocornine and RU 24213, on both basal prolactin release and thyrotropin releasing hormone-induced prolactin release. These experiments thus demonstrate a direct interference of dopamine action by a peripheral hormone. Prolactin secretion by pituitary cells in primary culture could possibly serve as an easily accessible model of a system under dopaminergic control.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)