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Science 2 June 1978:
Vol. 200. no. 4345, pp. 1069 - 1071
DOI: 10.1126/science.349691
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Articles

Science, Vol 200, Issue 4345, 1069-1071
Copyright © 1978 by American Association for the Advancement of Science

articles

Viremia in experimental Creutzfeldt-Jakob disease

EE Manuelidis, EJ Gorgacs, and L Manuelidis

Inoculation of the buffy coat of blood from guinea pigs infected with Creutzfeldt-Jakob disease resulted in passage of this disease to recipient animals. This demonstrates that there is a viremia in experimental Creutzfeldt-Jakob disease. These findings suggest that the hematogenous route may be implicated in the human infection and that the disease may possibly be transmitted by blood transfusions.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Virus-like interference in the latency and prevention of Creutzfeldt-Jakob disease.
L. Manuelidis and Z. Y. Lu (2003)
PNAS 100, 5360-5365
   Abstract »    Full Text »    PDF »
Microglia from Creutzfeldt-Jakob Disease-Infected Brains Are Infectious and Show Specific mRNA Activation Profiles.
C. A. Baker, D. Martin, and L. Manuelidis (2002)
J. Virol. 76, 10905-10913
   Abstract »    Full Text »    PDF »
Follicular Dendritic Cells and Dissemination of Creutzfeldt-Jakob Disease.
L. Manuelidis, I. Zaitsev, P. Koni, Z. Yun Lu, R. A. Flavell, and W. Fritch (2000)
J. Virol. 74, 8614-8622
   Abstract »    Full Text »
Microglial Activation Varies in Different Models of Creutzfeldt-Jakob Disease.
C. A. Baker, Z. Y. Lu, I. Zaitsev, and L. Manuelidis (1999)
J. Virol. 73, 5089-5097
   Abstract »    Full Text »
Novel proteinaceous infectious particles cause scrapie.
S. Prusiner (1982)
Science 216, 136-144
   Abstract »    PDF »
Precautions in Familial Transmissible Dementia: Including Familial Alzheimer's Disease.
R. H. Cook and J. H. Austin (1978)
Arch Neurol 35, 697-698
   Abstract »    PDF »
Neuroinvasion by a Creutzfeldt-Jakob disease agent in the absence of B cells and follicular dendritic cells.
M. J. Shlomchik, K. Radebold, N. Duclos, and L. Manuelidis (2001)
PNAS 98, 9289-9294
   Abstract »    Full Text »    PDF »


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