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Science 19 May 1978:
Vol. 200. no. 4343, pp. 793 - 794
DOI: 10.1126/science.565535
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Articles

Science, Vol 200, Issue 4343, 793-794
Copyright © 1978 by American Association for the Advancement of Science

articles

Cholecystokinin inhibits tail pinch-induced eating in rats

CB Nemeroff, AJ Osbahr 3rd, G Bissette, G Jahnke, MA Lipton, and AJ Prange

Peripheral administration of the COOH-terminal octapeptide of cholecystokinin in doses from 1 to 100 micrograms per kilogram of body weight (0.25 to 25.0 micrograms per rat) significantly antagonized tail pinch-induced eating in rats, an animal model for stress-induced human hyperphagia. Centrally administered cholecystokinin was effective only in high doses (3 micrograms into the cerebral ventricle). The finding that the minimal effective dose of cholecystokinin in suppressing stress-induced appetitive behavior is smaller after peripheral than central administration suggests that the peptide is acting on peripheral, as opposed to central nervous system, substrates.


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