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Science 12 May 1978:
Vol. 200. no. 4342, pp. 618 - 627
DOI: 10.1126/science.347575
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Articles

Science, Vol 200, Issue 4342, 618-627
Copyright © 1978 by American Association for the Advancement of Science

articles

Models for the specific adhesion of cells to cells

GI Bell

A theoretical framework is proposed for the analysis of adhesion between cells or of cells to surfaces when the adhesion is mediated by reversible bonds between specific molecules such as antigen and antibody, lectin and carbohydrate, or enzyme and substrate. From a knowledge of the reaction rates for reactants in solution and of their diffusion constants both in solution and on membranes, it is possible to estimate reaction rates for membrane-bound reactants. Two models are developed for predicting the rate of bond formation between cells and are compared with experiments. The force required to separate two cells is shown to be greater than the expected electrical forces between cells, and of the same order of magnitude as the forces required to pull gangliosides and perhaps some integral membrane proteins out of the cell membrane.


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For catch bonds, it all hinges on the interdomain region.
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Mechanics of actomyosin bonds in different nucleotide states are tuned to muscle contraction.
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J. Biol. Chem. 281, 16656-16663
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Microfluidic Techniques for Single-Cell Protein Expression Analysis.
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PNAS 103, 7222-7227
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Hsp70 chaperones accelerate protein translocation and the unfolding of stable protein aggregates by entropic pulling.
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PNAS 103, 6166-6171
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Elevated Shear Stress Protects Escherichia coli Cells Adhering to Surfaces via Catch Bonds from Detachment by Soluble Inhibitors.
L. M. Nilsson, W. E. Thomas, E. V. Sokurenko, and V. Vogel (2006)
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From the Cover: Molecular flexibility can influence the stimulatory ability of receptor-ligand interactions at cell-cell junctions.
S. Qi, M. Krogsgaard, M. M. Davis, and A. K. Chakraborty (2006)
PNAS 103, 4416-4421
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T cells like a firm molecular handshake.
M. L. Dustin and C. Zhu (2006)
PNAS 103, 4335-4336
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Regulation of N-Cadherin Dynamics at Neuronal Contacts by Ligand Binding and Cytoskeletal Coupling.
O. Thoumine, M. Lambert, R.-M. Mege, and D. Choquet (2006)
Mol. Biol. Cell 17, 862-875
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Detachment of affinity-captured bioparticles by elastic deformation of a macroporous hydrogel.
M. B. Dainiak, A. Kumar, I. Yu. Galaev, and B. Mattiasson (2006)
PNAS 103, 849-854
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Multiple stepwise refolding of immunoglobulin domain I27 upon force quench depends on initial conditions.
M. S. Li, C.-K. Hu, D. K. Klimov, and D. Thirumalai (2006)
PNAS 103, 93-98
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Single-molecule analysis of cadherin-mediated cell-cell adhesion.
P. Panorchan, M. S. Thompson, K. J. Davis, Y. Tseng, K. Konstantopoulos, and D. Wirtz (2006)
J. Cell Sci. 119, 66-74
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Single Molecule Adhesion Measurements Reveal Two Homophilic Neural Cell Adhesion Molecule Bonds with Mechanically Distinct Properties.
J. A. Wieland, A. A. Gewirth, and D. E. Leckband (2005)
J. Biol. Chem. 280, 41037-41046
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Single-Molecule Analysis of Human Immunodeficiency Virus Type 1 gp120-Receptor Interactions in Living Cells.
M. I. Chang, P. Panorchan, T. M. Dobrowsky, Y. Tseng, and D. Wirtz (2005)
J. Virol. 79, 14748-14755
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Cooperative cargo transport by several molecular motors.
S. Klumpp and R. Lipowsky (2005)
PNAS 102, 17284-17289
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Dynamic force spectroscopy of parallel individual Mucin1-antibody bonds.
T. A. Sulchek, R. W. Friddle, K. Langry, E. Y. Lau, H. Albrecht, T. V. Ratto, S. J. DeNardo, M. E. Colvin, and A. Noy (2005)
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Blood 106, 2944-2951
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PNAS 102, 13873-13878
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A Theoretical Framework for Quantitative Analysis of the Molecular Basis of Costimulation.
A. Jansson, E. Barnes, P. Klenerman, M. Harlen, P. Sorensen, S. J. Davis, and P. Nilsson (2005)
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From The Cover: Mechanics of receptor-mediated endocytosis.
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Growth and shape stability of a biological membrane adhesion complex in the diffusion-mediated regime.
V. B. Shenoy and L. B. Freund (2005)
PNAS 102, 3213-3218
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Dynamics of unbinding of cell adhesion molecules: Transition from catch to slip bonds.
V. Barsegov and D. Thirumalai (2005)
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Trans-bonded pairs of E-cadherin exhibit a remarkable hierarchy of mechanical strengths.
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PNAS 101, 16472-16477
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Exploring the energy landscape of GFP by single-molecule mechanical experiments.
H. Dietz and M. Rief (2004)
PNAS 101, 16192-16197
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Differential actin binding along the PEVK domain of skeletal muscle titin.
A. Nagy, P. Cacciafesta, L. Grama, A. Kengyel, A. Malnasi-Csizmadia, and M. S. Z. Kellermayer (2004)
J. Cell Sci. 117, 5781-5789
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Chemistry on a Single Protein, Vascular Cell Adhesion Molecule-1, during Forced Unfolding.
N. Bhasin, P. Carl, S. Harper, G. Feng, H. Lu, D. W. Speicher, and D. E. Discher (2004)
J. Biol. Chem. 279, 45865-45874
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Catch bonds govern adhesion through L-selectin at threshold shear.
T. Yago, J. Wu, C. D. Wey, A. G. Klopocki, C. Zhu, and R. P. McEver (2004)
J. Cell Biol. 166, 913-923
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Direct quantification of the modulation of interaction between cell- or surface-bound LFA-1 and ICAM-1.
J. Vitte, A. Pierres, A.-M. Benoliel, and P. Bongrand (2004)
J. Leukoc. Biol. 76, 594-602
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Cell mechanosensitivity controls the anisotropy of focal adhesions.
A. Nicolas, B. Geiger, and S. A. Safran (2004)
PNAS 101, 12520-12525
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Nucleic acid transport through carbon nanotube membranes.
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PNAS 101, 12177-12182
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Mechanical switching and coupling between two dissociation pathways in a P-selectin adhesion bond.
E. Evans, A. Leung, V. Heinrich, and C. Zhu (2004)
PNAS 101, 11281-11286
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A Stochastic Process Algebra Approach to Simulation of Autoreactive Lymphocyte Recruitment.
P. Lecca, C. Priami, P. Quaglia, B. Rossi, C. Laudanna, and G. Constantin (2004)
SIMULATION 80, 273-288
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Distinct kinetic and mechanical properties govern selectin-leukocyte interactions.
W. D. Hanley, D. Wirtz, and K. Konstantopoulos (2004)
J. Cell Sci. 117, 2503-2511
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The unfolding kinetics of ubiquitin captured with single-molecule force-clamp techniques.
M. Schlierf, H. Li, and J. M. Fernandez (2004)
PNAS 101, 7299-7304
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From The Cover: L-selectin-mediated leukocyte tethering in shear flow is controlled by multiple contacts and cytoskeletal anchorage facilitating fast rebinding events.
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PNAS 101, 6940-6945
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J. Biol. Chem. 279, 2291-2298
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Dynamics of the interaction between a fibronectin molecule and a living bacterium under mechanical force.
Y. Bustanji, C. R. Arciola, M. Conti, E. Mandello, L. Montanaro, and B. Samori (2003)
PNAS 100, 13292-13297
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Avidity enhancement of L-selectin bonds by flow: shear-promoted rotation of leukocytes turn labile bonds into functional tethers.
O. Dwir, A. Solomon, S. Mangan, G. S. Kansas, U. S. Schwarz, and R. Alon (2003)
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