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Science 5 May 1978:
Vol. 200. no. 4341, pp. 559 - 561
DOI: 10.1126/science.565534
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Articles

Science, Vol 200, Issue 4341, 559-561
Copyright © 1978 by American Association for the Advancement of Science

articles

Diazepam inhibits myoblast fusion and expression of muscle specific protein synthesis

E Bandman, CR Walker, and RC Strohman

The presence of diazepam in culutres of chicken embryo myoblasts arrests normal muscle cell differentiation. High concentrations of the drug reversibly prevent myoblasts from fusing to form multinucleated myotubes. Lower concentrations of diazepam allow cell fusion to occur, but inhibit the synthesis and accumulation of myosin heavy chain, implying that cell fusion does not obligate myoblasts to synthesize and accumulate large quantities of muscle specific protein. The effect of diazepam on muscle cells in culture is direct and specific.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Tumor selective G2/M cell cycle arrest and apoptosis of epithelial and hematological malignancies by BBL22, a benzazepine.
W. Xia, S. Spector, L. Hardy, S. Zhao, A. Saluk, L. Alemane, and N. L. Spector (2000)
PNAS 97, 7494-7499
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