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Science 5 May 1978:
Vol. 200. no. 4341, pp. 556 - 559
DOI: 10.1126/science.644318
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Articles

Science, Vol 200, Issue 4341, 556-559
Copyright © 1978 by American Association for the Advancement of Science

articles

Tumor promoters inhibit morphological differentiation in cultured mouse neuroblastoma cells

DN Ishii, E Fibach, H Yamasaki, and IB Weinstein

When added to mouse neuroblastoma cultures, the potent tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) inhibits spontaneous neurite formation as well as that induced in response to serum deprivation, prostaglandin E1, 5-bromo-2'-deoxyuridine, and papaverine. Other tumor-promoting macrocyclic plant diterpenes also inhibit neurite formation, whereas nonpromoting diterpenes do not. Inhibition by TPA was reversible and was unrelated to toxicity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Tumor-promoting phorbol esters stimulate hematopoietic colony formation in vitro.
R. Stuart and J. Hamilton (1980)
Science 208, 402-404
   Abstract »    PDF »
Induction of differentiation in human promyelocytic leukemia cells by tumor promoters.
G Rovera, T. O'Brien, and L Diamond (1979)
Science 204, 868-870
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)