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Science 5 May 1978:
Vol. 200. no. 4341, pp. 541 - 543
DOI: 10.1126/science.644314
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Articles

Science, Vol 200, Issue 4341, 541-543
Copyright © 1978 by American Association for the Advancement of Science

articles

Delayed hypersensitivity in man: effects of systemic anticoagulation

RL Edwards and FR Rickles

Skin test reactivity, lymphocyte transformation, and mononuclear cell tissue factor generation were evaluated both before and during systemic anticoagulation in 24 volunteers. Anticoagulation with warfarin decreased skin test induration and tissue factor generation, but lymphocyte trnasformation remained unchanged. An intact coagulation mechanism, including tissue factor generation, appears to be important for the development of skin test induration in humans.


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