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Science 5 May 1978:
Vol. 200. no. 4341, pp. 539 - 541
DOI: 10.1126/science.644313
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Articles

Science, Vol 200, Issue 4341, 539-541
Copyright © 1978 by American Association for the Advancement of Science

articles

Ah locus: genetic differences in susceptibility to cataracts induced by acetaminophen

H Shichi, DE Gaasterland, NM Jensen, and DW Nebert

The Ahb/Ahb homozygous and the Ahb/Ahd heterozygous inbred mouse strains from the (C57BL/6)(DBA/2)F1 X DBA/2 backcross are genetically responsive to 3-methylcholanthrene. They both also develop, within 6 hours after a large intraperitoneal dose of acetaminophen, an irreversible opacity in the anterior portion of the lens. Such cataract formation does not occur in similarly treated nonresponsive inbred strains or nonresponsive Ahd/Ahd individuals from the same backcross. Differences in acetaminophen metabolism and toxicity are associated with the Ah locus in the mouse, and differences in heritability at the Ah locus exist in the human. Our ophthalmologic findings may be important clinically to certain patients receiving either a single large overdose of this drug or high doses over a long period.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Accelerated cataract formation and reduced lens epithelial water permeability in aquaporin-1-deficient mice..
J. Ruiz-Ederra and A. S. Verkman (2006)
Invest. Ophthalmol. Vis. Sci. 47, 3960-3967
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Science. ISSN 0036-8075 (print), 1095-9203 (online)