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Science 5 May 1978:
Vol. 200. no. 4341, pp. 494 - 502
DOI: 10.1126/science.205947
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Articles

Science, Vol 200, Issue 4341, 494-502
Copyright © 1978 by American Association for the Advancement of Science

articles

The genome of simian virus 40

VB Reddy, B Thimmappaya, R Dhar, KN Subramanian, BS Zain, J Pan, PK Ghosh, ML Celma, and SM Weissman

The nucleotide sequence of SV40 DNA was determined, and the sequence was correlated with known genes of the virus and with the structure of viral messenger RNA's. There is a limited overlap of the coding regions for structural proteins and a complex pattern of leader sequences at the 5' end of late messenger RNA. The sequence of the early region is consistent with recent proposals that the large early polypeptide of SV40 is encoded in noncontinguous segments of DNA.


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Phosphorylation of SV40 Large T Antigen.
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T Antigens of SV40-transformed Cells.
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T-antigen-associated Proteins Induced by SV40 Transformation.
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Deletion Mutants of SV40 That Affect the Structure of Viral Tumor Antigens.
J. M. Pipas, S. P. Adler, K. W. C. Peden, and D. Nathans (1980)
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Origin-defective Mutants of SV40.
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SV40 Mutant tsA1499 Is Heat-sensitive for Lytic Growth but Generates Cold-sensitive Rat-cell Transformants.
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Biogenesis, Structures, and Sites of Encoding of the 5' Termini of Adenovirus-2 mRNAs.
C. C. Baker and E. B. Ziff (1980)
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Mechanism for Circularization of MVM DNA by "Noose" Sliding in a Lassolike Structure: Implication for Integration.
Y. Aloni, S. Bratosin, O. Laub, and J. Tal (1980)
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Tumorigenicity of Polyoma Virus in Hamsters.
M. A. Israel, K. Chowdhury, J. Ramseur, K. Chandrasekaran, D. F. Vanderryn, and M. A. Martin (1980)
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Sequence of the cloned gene for the constant region of murine gamma 2b immunoglobulin heavy chain.
P. Tucker, K. Marcu, N Newell, J Richards, and F. Blattner (1979)
Science 206, 1303-1306
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Restriction endonucleases, simian virus 40, and the new genetics.
D Nathans (1979)
Science 206, 903-909
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BK virus DNA: complete nucleotide sequence of a human tumor virus.
R. Yang and R Wu (1979)
Science 206, 456-462
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A relationship between DNA helix stability and recognition sites for RNA polymerase.
H. Vollenweider, M Fiandt, and W Szybalski (1979)
Science 205, 508-511
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Split genes and RNA splicing.
F Crick (1979)
Science 204, 264-271
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Structure and Activities of Escherichia coli DNA Gyrase.
C. L. Peebles, N. P. Higgins, K. N. Kreuzer, A. Morrison, P. O. Brown, A. Sugino, and N. R. Cozzarelli (1979)
Cold Spring Harb Symp Quant Biol 43, 41-52
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Protein-DNA Interactions at the Origin of Simian Virus 40 DNA Replication.
R. Tjian (1979)
Cold Spring Harb Symp Quant Biol 43, 655-662
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Replication and Structure of Simian Virus 40 Chromosomes.
M. L. DePamphilis, S. Anderson, R. Bar-Shavit, E. Collins, H. Edenberg, T. Herman, B. Karas, G. Kaufmann, H. Krokan, E. Shelton, et al. (1979)
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