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Science 28 April 1978:
Vol. 200. no. 4340, pp. 435 - 437
DOI: 10.1126/science.77040
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Articles

Science, Vol 200, Issue 4340, 435-437
Copyright © 1978 by American Association for the Advancement of Science

articles

Channel structures of gramicidin: characterization of succinyl derivatives

RJ Bradley, DW Urry, K Okamoto, and R Rapaka

Succinyl derivatives of gramicidin were tested for their ability to form channels in planar artificial lipid bilayers. Both N-succinyldeformylgramicidin methyl ester and charged O-succinylgramicidin formed channels, but the channels had markedly different sizes and lifetimes. This implies that gramicidin forms channels by end-to-end association. However, the doubly charged N,O-bissuccinyldeformylgramicidin was inactive, which suggests that only end-to-end association of gramicidin may result in channel formation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
N-acetyl gramicidin: single-channel properties and implications for channel structure.
G Szabo and D. Urry (1979)
Science 203, 55-57
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