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Science 21 April 1978:
Vol. 200. no. 4339, pp. 327 - 329
DOI: 10.1126/science.416494
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Articles

Science, Vol 200, Issue 4339, 327-329
Copyright © 1978 by American Association for the Advancement of Science

articles

Hv(1), a variable-region genetic marker of human immunoglobulin heavy chains

AC Wang, S Mathur, J Pandey, FP Siegel, CR Middaugh, and GW Litman

A new antigenic determinant was discovered with a hemagglutination-inhibition assay system. Designated Hv(1), it is located in the variable region of human immunoglobulin heavy chains of the G, M, and A classes. Pedigree and population analyses suggest that it has an autosomal dominant mode of inheritance. This represents the first description of an allotypic determinant in the variable region of human immunoglobulins.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)