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Science 7 April 1978:
Vol. 200. no. 4337, pp. 62 - 64
DOI: 10.1126/science.204996
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Articles

Science, Vol 200, Issue 4337, 62-64
Copyright © 1978 by American Association for the Advancement of Science

articles

Preferential utilization of free cholesterol from high-density lipoproteins for biliary cholesterol secretion in man

CC Schwartz, LG Halloran, ZR Vlahcevic, DH Gregory, and L Swell

High- and low-density lipoproteins carrying free cholesterol labeled with 3H or 14C were administered to a patient with a bile fistula. The free cholesterol from high-density lipoproteins was more rapidly incorporated into biliary cholesterol than the free cholesterol from low-density lipoproteins. These findings show that the liver in man selectively utilizes and secretes the free cholesterol from a particular lipoprotein.


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