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Science 7 April 1978:
Vol. 200. no. 4337, pp. 50 - 51
DOI: 10.1126/science.635570
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Articles

Science, Vol 200, Issue 4337, 50-51
Copyright © 1978 by American Association for the Advancement of Science

articles

Muscular dystrophy: inhibition of degeneration in vivo with protease inhibitors

A Stracher, EB McGowan, and SA Shafiq

The protease inhibitors leupeptin and pepstatin were used in vivo in genetically dystrophic chickens to determine their effects on the histological and biochemical changes observed in this disease. These compounds appear to delay the degeneration of muscle tissue which is characteristic of this disorder and thus may have potential therapeutic value in the treatment of muscular dystrophy.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)