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Science 31 March 1978:
Vol. 199. no. 4336, pp. 1449 - 1451
DOI: 10.1126/science.204015
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Articles

Science, Vol 199, Issue 4336, 1449-1451
Copyright © 1978 by American Association for the Advancement of Science

articles

Specific-opiate-induced depression of transmitter release from dorsal root ganglion cells in culture

RL Macdonald and PG Nelson

The opiate etorphine depresses monosynaptic excitatory postsynaptic potentials (EPSP's) elicited in spinal cord cells by activation of dorsal root ganglion cells in murine neuronal cell culture. The depression is reversed by naloxone. Statistical analysis of the synaptic responses reveals that the opiate reduces EPSP quantal content at this synapse without altering quantal size. Therefore, the opiate action is presynaptic and affects transmitter release rather than postsynaptic responsiveness.


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Dynorphin Exerts Both Postsynaptic and Presynaptic Effects in the Globus Pallidus of the Rat.
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Glycine and GABAA receptor-mediated synaptic transmission in rat substantia gelatinosa: inhibition by {micro}-opioid and GABAB agonists.
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J. Physiol. 507, 473-483
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Endogenous Opioid Peptides Acting at µ-Opioid Receptors in the Dorsal Horn Contribute to Midbrain Modulation of Spinal Nociceptive Neurons.
D. Budai and H. L. Fields (1998)
J Neurophysiol 79, 677-687
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Nociceptin Inhibits T-Type Ca2+ Channel Current in Rat Sensory Neurons by a G-Protein-Independent Mechanism.
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kappa -Opioid Receptor Activation Modulates Ca2+ Currents and Secretion in Isolated Neuroendocrine Nerve Terminals.
K. I. Rusin, D. R. Giovannucci, E. L. Stuenkel, and H. C. Moises (1997)
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Activation of delta -Opioid Receptors Inhibits Neuronal-Like Calcium Channels and Distal Steps of Ca2+-Dependent Secretion in Human Small-Cell Lung Carcinoma Cells.
E. Sher, P. Cesare, A. Codignola, F. Clementi, P. Tarroni, A. Pollo, V. Magnelli, and E. Carbone (1996)
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Attenuation of the Exercise Pressor Reflex : Effect of Opioid Agonist on Substance P Release in L-7 Dorsal Horn of Cats.
A. F. Meintjes, A. C. L. Nobrega, I. E. Fuchs, A. Ally, and L. B. Wilson (1995)
Circ. Res. 77, 326-334
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Opiates and pain pathways: demonstration of enkephalin synapses on dorsal horn projection neurons.
M. Ruda (1982)
Science 215, 1523-1525
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Heterodimerization of {micro} and delta Opioid Receptors: A Role in Opiate Synergy.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)