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Science 31 March 1978:
Vol. 199. no. 4336, pp. 1439 - 1441
DOI: 10.1126/science.204013
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Articles

Science, Vol 199, Issue 4336, 1439-1441
Copyright © 1978 by American Association for the Advancement of Science

articles

Production of antibody to tetanus toxoid by continuous human lymphoblastoid cell lines

VR Zurawski Jr, E Haber, and PH Black

Peripheral lymphocytes from human volunteers boosted with tetanus toxoid were cultured after in vitro infection with Epstein-Barr virus. Forty-four continuous lymphoblastoid lines were established which continued to secrete human gamma globulin; seven of these secreted antibody to tetanus toxoid. Subcultures derived from limiting dilution experiments continued to secrete the antibody. Some of these antibody-secreting cells have been in continuous culture for more than 6 months.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Latent Herpesviruses of Humans.
M. C. JORDAN, G. W. JORDAN, J. G. STEVENS, and G. MILLER (1984)
Ann Intern Med 100, 866-880
   Abstract »    PDF »
Herpes simplex virus glycoprotein D: human monoclonal antibody produced by bone marrow cell line.
J. Seigneurin, C Desgranges, D Seigneurin, J Paire, J. Renversez, B Jacquemont, and C Micouin (1983)
Science 221, 173-175
   Abstract »    PDF »


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