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Science 24 March 1978:
Vol. 199. no. 4335, pp. 1359 - 1362
DOI: 10.1126/science.204012
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Articles

Science, Vol 199, Issue 4335, 1359-1362
Copyright © 1978 by American Association for the Advancement of Science

articles

Dual actions of substance P on nociception: possible role of endogenous opioids

RC Frederickson, V Burgis, CE Harrell, and JD Edwards

Substance P produces analgesia when administered to mice in very small doses by the intraventricular route (1.25 to 5 nanograms per mouse). The analgesic effect can be blocked by naloxone. At higher doses (greater than 50 nanograms per mouse), this activity is lost. At these higher doses, however, substance P produced hyperalgesia when combined with naloxone and analgesia when combined with baclofen [beta-(4-chlorophenyl)-gamma-aminobutyric acid]. Substance P may have dual actions in brain, releasing endorphins at very low doses and directly exciting neuronal activity in nociceptive pathways at higher doses.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Substance P Drives Endocannabinoid-Mediated Disinhibition in a Midbrain Descending Analgesic Pathway.
G. M. Drew, B. K. Lau, and C. W. Vaughan (2009)
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The Tachykinin Peptide Family.
C. Severini, G. Improta, G. Falconieri-Erspamer, S. Salvadori, and V. Erspamer (2002)
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Inhibition of Morphine Tolerance Development by a Substance P-Opioid Peptide Chimera.
S. E. Foran, D. B. Carr, A. W. Lipkowski, I. Maszczynska, J. E. Marchand, A. Misicka, M. Beinborn, A. S. Kopin, and R. M. Kream (2000)
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Substance P Release in the Rat Periaqueductal Gray and Preoptic Anterior Hypothalamus after Noxious Cold Stimulation: Effect of Selective Mu and Kappa Opioid Agonists.
L. Xin, E. B. Geller, L.-Y. Liu-Chen, C. Chen, and M. W. Adler (1997)
J. Pharmacol. Exp. Ther. 282, 1055-1063
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Sensory and motor functions of spinal cord substance P.
M. Piercey, L. Schroeder, K Folkers, J. Xu, and J Horig (1981)
Science 214, 1361-1363
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Substance P: does it produce analgesia or hyperalgesia?.
P Oehme, H Hilse, E Morgenstern, and E Gores (1980)
Science 208, 305-307
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A substance P-opioid chimeric peptide as a unique nontolerance-forming analgesic.
S. E. Foran, D. B. Carr, A. W. Lipkowski, I. Maszczynska, J. E. Marchand, A. Misicka, M. Beinborn, A. S. Kopin, and R. M. Kream (2000)
PNAS 97, 7621-7626
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