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Science 24 March 1978:
Vol. 199. no. 4335, pp. 1345 - 1346
DOI: 10.1126/science.628842
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Articles
Science, Vol 199, Issue 4335, 1345-1346
Copyright © 1978 by American Association for the Advancement of Science
Nonhistone proteins HMG1 and HMG2 change the DNA helical structure
K Javaherian,
JF Liu,
and
JC Wang
Two chromatin nonhistone proteins (from calf thymus) of the high mobility group, HMG1 and HMG2, reduce the linking number (topological winding number) of a circular DNA if the covalent closure of the DNA is carried out in their presence. This indicates that these proteins can either unwind the double helix, or induce a supercoiling of the DNA.
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