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Science 24 March 1978:
Vol. 199. no. 4335, pp. 1340 - 1342
DOI: 10.1126/science.628841
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Articles

Science, Vol 199, Issue 4335, 1340-1342
Copyright © 1978 by American Association for the Advancement of Science

articles

Increased resistance to Staphylococcus aureus infection and enhancement in serum lysozyme activity by glucan

PL Kokoshis, DL Williams, JA Cook, and NR Di Luzio

Glucan is a potent reticuloendothelial stimulant whose immunobiological activity is mediated, in part, by an increase in the number and function of macrophages. In studying the role of glucan as a mediator of antibacterial activity, we attempted to ascertain the ability of glucan to modify the mortality of mice with experimentally induced Gram-positive bacteremia, and to enhance antibacterial defenses in rats as denoted by serum lysozyme and phagocytic activity. After intravenous administration of glucan, serum lysozyme concentrations were increased approximately sevenfold over control concentrations. The increase in serum lysozyme appeared to parallel the glucan-induced increase in phagocytosis and induced hyperplasia of macrophages. Prior treatment of mice with glucan significantly enhanced their survival when they were challenged systemically with Staphylococcus aureus. These studies indicate that glucan confers an enhanced state of host defense against bacterial infections.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
{beta}-Glucan Activates Microglia without Inducing Cytokine Production in Dectin-1-Dependent Manner.
V. B. Shah, Y. Huang, R. Keshwara, T. Ozment-Skelton, D. L. Williams, and L. Keshvara (2008)
J. Immunol. 180, 2777-2785
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The {beta}-Glucan Receptor, Dectin-1, Is Predominantly Expressed on the Surface of Cells of the Monocyte/Macrophage and Neutrophil Lineages.
P. R. Taylor, G. D. Brown, D. M. Reid, J. A. Willment, L. Martinez-Pomares, S. Gordon, and S. Y. C. Wong (2002)
J. Immunol. 169, 3876-3882
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Polysaccharide purified from Ganoderma lucidum inhibits spontaneous and Fas-mediated apoptosis in human neutrophils through activation of the phosphatidylinositol 3 kinase/Akt signaling pathway.
M.-J. Hsu, S.-S. Lee, and W.-W. Lin (2002)
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A Helix-Loop-Helix Peptide at the Upper Lip of the Active Site Cleft of Lysozyme Confers Potent Antimicrobial Activity with Membrane Permeabilization Action.
H. R. Ibrahim, U. Thomas, and A. Pellegrini (2001)
J. Biol. Chem. 276, 43767-43774
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Characterization of the Human beta -Glucan Receptor and Its Alternatively Spliced Isoforms.
J. A. Willment, S. Gordon, and G. D. Brown (2001)
J. Biol. Chem. 276, 43818-43823
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Reduction of Infection-stimulated Periapical Bone Resorption by the Biological Response Modifier PGG Glucan.
P. Stashenko, C.Y. Wang, E. Riley, Y. Wu, G. Ostroff, and R. Niederman (1995)
Journal of Dental Research 74, 323-330
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Microbial Infection and the Septic Response in Critical Surgical Illness: Sepsis, Not Infection, Determines Outcome.
J. Marshall and D. Sweeney (1990)
Arch Surg 125, 17-23
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Glucan-induced modification of murine viral hepatitis.
D. Williams and N. Di Luzio (1980)
Science 208, 67-69
   Abstract »    PDF »


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