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Science 10 March 1978:
Vol. 199. no. 4333, pp. 1080 - 1082
DOI: 10.1126/science.75568
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Articles

Science, Vol 199, Issue 4333, 1080-1082
Copyright © 1978 by American Association for the Advancement of Science

articles

Direct demonstration and quantitation of the first complement component in human serum

RJ Ziccardi and NR Cooper

The first component of complement, C1, can be demonstrated and quantitated in normal and pathological human serums by simple immunochemical techniques. All of the C1q, C1r, and C1s detected in normal serum was found to be in the C1 complex. A simple modification of these methods permitted the quantitation of free C1s in the presence of macromolecular C1, a technique which may prove useful in screening pathological serums.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Surfactant Protein A Regulates Complement Activation.
W. T. Watford, J. R. Wright, C. G. Hester, H. Jiang, and M. M. Frank (2001)
J. Immunol. 167, 6593-6600
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