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Science 10 March 1978:
Vol. 199. no. 4333, pp. 1072 - 1075
DOI: 10.1126/science.628831
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Articles

Science, Vol 199, Issue 4333, 1072-1075
Copyright © 1978 by American Association for the Advancement of Science

articles

Rabies viruses increase in virulence when propagated in neuroblastoma cell culture

HF Clark

Several strains of attenuated rabies virus lacking the capacity to kill adult mice acquired a high lethal potential for mice after one to five serial passages in murine or human neuroblastoma cells. The virulence acquired after passage in neuroblastoma cells is a stable genetic trait retained during subsequent passage of viruses in nonneuroblastoma cell systems.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)