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Science 17 February 1978:
Vol. 199. no. 4330, pp. 798 - 801
DOI: 10.1126/science.622571
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Articles

Science, Vol 199, Issue 4330, 798-801
Copyright © 1978 by American Association for the Advancement of Science

articles

Command neurons in Pleurobranchaea receive synaptic feedback from the motor network they excite

R Gillette, MP Kovac, and WJ Davis

Command neurons that cause rhythmic feeding behavior in the marine mollusc Pleurobranchaea californica have been identified in the cerebropleural ganglion (brain). Intracellular stimulation of single command neurons in isolated nervous systems, semi-intact prepartions, and restrained whole animals causes the same rhythmic motor output pattern as occurs during feeding. During this motor output pattern, action potentials recorded intracellularly from the command neurons occur in cyclic bursts that are phase-locked with the feeding rhythm. This modulation results from repetitive, alternating bursts of excitatory and inhibitory postsynaptic potentials, which are caused at least in part by synaptic feedback to the command neurons from identified classes of neurons in the feeding network. Central feedback to command neurons from the motor network they excite provides a possible general physiological mechanism for the sustained oscillation of neural networks controlling cyclic behavior.


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