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Science 17 February 1978:
Vol. 199. no. 4330, pp. 788 - 790
DOI: 10.1126/science.622570
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Articles

Science, Vol 199, Issue 4330, 788-790
Copyright © 1978 by American Association for the Advancement of Science

articles

Amantadine: neuromuscular blockade by suppression of ionic conductance of the acetylcholine receptor

EX Albuquerque, AT Eldefrawi, ME Eldefrawi, NA Mansour, and MC Tsai

Amantadine hydrochloride decreases the sensitivity of denervated mammalian muscle to iontophoretically applied acetylcholine. The drug depresses the amplitude of the end-plate current and reverses the slope of the relation between half-decay time and membrane potential suggesting that it alters the ionic conductance that is mediated by the acetylcholine receptor. Binding studies confirm that amantadine acts on the ion conductance modulator rather than the acetylcholine receptor.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Open-Channel Blockers at the Human alpha 4beta 2 Neuronal Nicotinic Acetylcholine Receptor.
B. Buisson and D. Bertrand (1998)
Mol. Pharmacol. 53, 555-563
   Abstract »    Full Text »
Amantadine Inhibits Nicotinic Acetylcholine Receptor Function in Hippocampal Neurons.
H. Matsubayashi, K. L. Swanson, and E. X. Albuquerque (1997)
J. Pharmacol. Exp. Ther. 281, 834-844
   Abstract »    Full Text »


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