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Science 17 February 1978:
Vol. 199. no. 4330, pp. 781 - 782
DOI: 10.1126/science.622567
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Articles

Science, Vol 199, Issue 4330, 781-782
Copyright © 1978 by American Association for the Advancement of Science

articles

Chronologic and physiologic age affect replicative life-span of fibroblasts from diabetic, prediabetic, and normal donors

S Goldstein, EJ Moerman, JS Soeldner, RE Gleason, and DM Barnett

Cultured skin fibroblasts from subjects with clinically apparent diabetes mellitus and from subjects genetically predisposed to diabetes have a replicative lifespan that is inversely related to donor age. Fibroblasts from carefully defined normal subjects not predisposed to diabetes fail to show this correlation. The data support the idea that physiologic status of the tissue donor is a more precise determinant of fibroblast replicative lifespan than chronologic age.


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