Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 10 February 1978:
Vol. 199. no. 4329, pp. 690 - 692
DOI: 10.1126/science.625660
Prev | Table of Contents | Next

Articles

Science, Vol 199, Issue 4329, 690-692
Copyright © 1978 by American Association for the Advancement of Science

articles

DNA synthesis in cartilage cells is stimulated by oscillating electric fields

GA Rodan, LA Bourret, and LA Norton

External oscillating electric fields (1166 volts per centimeter, 5 hertz) enhanced the incorporation of [3H] thymidine into the DNA of chondrocytes isolated from the proliferative layer of embryonic (16 days) chick epiphysis. Verapamil or tetrodotoxin at 10(-6)M concentrations completely blocked the electric field effect. Tetracaine reduced the incorporation of [3H] thymidine in both control and electrically stimulated cells. The findings support the hypothesis that Na and Ca2 fluxes generated by the electrical perturbation trigger DNA synthesis in these cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Biochemical and morphological study of human articular chondrocytes cultivated in the presence of pulsed signal therapy.
A Fioravanti, F Nerucci, G Collodel, R Markoll, and R Marcolongo (2002)
Ann Rheum Dis 61, 1032-1033
   Full Text »
Pulsating Electromagnetic Field Stimulates mRNA Expression of Bone Morphogenetic Protein-2 and -4.
M. Nagai and M. Ota (1994)
Journal of Dental Research 73, 1601-1605
   Abstract »    PDF »
Effect of a Pulsing Electromagnetic Field on Demineralized Bone-matrix-induced Bone Formation in a Bony Defect in the Premaxilla of Rats.
T. Takano-Yamamoto, M. Kawakami, and M. Sakuda (1992)
Journal of Dental Research 71, 1920-1925
   Abstract »    PDF »
The Effect of Constant Direct Electrical Current on Intrinsic Healing in the Flexor Tendon in Vitro: An ultrastructural study of differing attitudes in epitenon cells and tenocytes.
M. FUJITA, S. HUKUDA, and Y. DOIDA (1992)
J Hand Surg Eur Vol. 17, 94-98
   Abstract »    PDF »
Frequency dependence of electric field modulation of fibroblast protein synthesis.
K. McLeod, R. Lee, and H. Ehrlich (1987)
Science 236, 1465-1469
   Abstract »    PDF »
Time-varying magnetic fields: effect on DNA synthesis.
A. Liboff, T Williams Jr, D. Strong, and R Wistar Jr (1984)
Science 223, 818-820
   Abstract »    PDF »
Electrical Treatment of Severe Head and Neck Cancer Pain.
W. Bauer (1983)
Arch Otolaryngol Head Neck Surg 109, 382-383
   Abstract »    PDF »
Kinetics of Cell Proliferation and Migration Associated with Orthodontically-induced Osteogenesis.
W. EugeneRoberts and D. C. Chase (1981)
Journal of Dental Research 60, 174-181
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)