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Science 10 February 1978:
Vol. 199. no. 4329, pp. 688 - 690
DOI: 10.1126/science.415360
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Articles

Science, Vol 199, Issue 4329, 688-690
Copyright © 1978 by American Association for the Advancement of Science

articles

Covalent immunoglobulin assembly in vitro: reactivity of light chain covalent dimers (L2) and blocked light chain monomers

AR Kazin and S Beychok

Covalent light chain dimers (L2) and cysteine-blocked L chain monomers readily react with partially reduced heavy (H) chains. A rapid disappearance of these blocked L chain species is followed by the appearance of covalent intermediates-HL, H2, and H2L-leading to fully assembled H2L2. The mechanism of initial disulfide bond formation between heavy and light chains is disulfide interchange.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)