Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 10 February 1978:
Vol. 199. no. 4329, pp. 686 - 688
DOI: 10.1126/science.204004
Prev | Table of Contents | Next

Articles

Science, Vol 199, Issue 4329, 686-688
Copyright © 1978 by American Association for the Advancement of Science

articles

Fasting decreases triiodothyronine receptor capacity

GC Schussler and J Orlando

Fasting decreases the ratio of hepatic nuclear to serum triiodothyronine (T3) by diminishing the binding capacity of nuclear T3 receptors. In combination with the lower serum T3 concentration caused by fasting, the decrease in receptor content results in a marked decrease in nuclear T3-receptor complexes. The changes in T3 receptor content and circulating T3 in fasted animals appear to be independent synergistic adaptations for caloric conservation in the fasted state. Unlike changes in hormonal level, the modification of nuclear receptor content provides a mechanism that may protect cells with a low caloric reserve independently of the metabolic status of the whole animal.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Na+-K+ Pump Regulation and Skeletal Muscle Contractility.
T. CLAUSEN (2003)
Physiol Rev 83, 1269-1324
   Abstract »    Full Text »    PDF »
Associations between Weight Loss-Induced Changes in Plasma Organochlorine Concentrations, Serum T3 Concentration, and Resting Metabolic Rate.
C. Pelletier, E. Doucet, P. Imbeault, and A. Tremblay (2002)
Toxicol. Sci. 67, 46-51
   Abstract »    Full Text »    PDF »
Thyroid Function in Nonthyroidal Illnesses.
I. J. CHOPRA, J. M. HERSHMAN, W. M. PARDRIDGE, and J. T. NICOLOFF (1983)
Ann Intern Med 98, 946-957
   Abstract »    PDF »
Starvation-induced decreased sensitivity of resting metabolic rate to triiodothyronine.
C Wimpfheimer, E Saville, M. Voirol, E Danforth Jr, and A. Burger (1979)
Science 205, 1272-1273
   Abstract »    PDF »
Thyroid hormone action at the cellular level.
J. Oppenheimer (1979)
Science 203, 971-979
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)