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Science 3 February 1978:
Vol. 199. no. 4328, pp. 552 - 555
DOI: 10.1126/science.304600
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Articles

Science, Vol 199, Issue 4328, 552-555
Copyright © 1978 by American Association for the Advancement of Science

articles

Limitation of excessive myelopoiesis by the intrinsic modulation of macrophage-derived prostaglandin E

JI Kurland, RS Bockman, HE Broxmeyer, and MA Moore

The clonal proliferation of the committed granulocyte-macrophage stem cell is controlled by a balance between mutually opposing factors, colony stimulating factor and prostaglandin E, both of monocyte-macrophage derivation. Increases beyond a critical concentration of colony stimulating factor within the local milieu of the mononuclear phagocyte induces the coincident elaboration of prostaglandin E, a self-regulated response which serves to limit the unopposed humoral stimulation of myelopoiesis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
In vivo prostaglandin E2 treatment alters the bone marrow microenvironment and preferentially expands short-term hematopoietic stem cells.
B. J. Frisch, R. L. Porter, B. J. Gigliotti, A. J. Olm-Shipman, J. M. Weber, R. J. O'Keefe, C. T. Jordan, and L. M. Calvi (2009)
Blood 114, 4054-4063
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Endogenous regulation of macrophage proliferative expansion by colony-stimulating factor-induced interferon.
R. Moore, H. Larsen, D. Horohov, and B. Rouse (1984)
Science 223, 178-181
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Suppression of Granulopoiesis by T-Lymphocytes in Two Patients with Disseminated Mycobacterial Infection.
G. C. BAGBY Jr. and D. N. GILBERT (1981)
Ann Intern Med 94, 478-481
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The Histiocytic Disorders: A Pathophysiologic Analysis.
J. E. GROOPMAN and D. W. GOLDE (1981)
Ann Intern Med 94, 95-107
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Growth Factors.
D. W. GOLDE, H. R. HERSCHMAN, A. J. LUSIS, and J. E. GROOPMAN (1980)
Ann Intern Med 92, 650-662
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