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Science 3 February 1978:
Vol. 199. no. 4328, pp. 539 - 541
DOI: 10.1126/science.203031
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Articles

Science, Vol 199, Issue 4328, 539-541
Copyright © 1978 by American Association for the Advancement of Science

articles

Sodium requirement for the positive inotropic action of isoproterenol on guinea pig atria

J Linden and G Brooker

Isoproterenol doses not elicit its characteristic positive inotropic action in contracting guinea pig atria suspended in sodium-free media. However, the ability of isoproterenol to decrease the time to peak tension development during an individual contraction cycle is still present in sodium-free solutions. Removal of sodium diminished but did not eliminate the tissues' ability to elevate adenosine 3',5'-monophosphate in response to isoproterenol. The striking absence of an inotropic action by isoproterenol on atria in sodium-free media suggests that sodium (and possibly a sodium-calcium exchange across the sarcolemma) plays an important role in the inotropic action of catecholamines.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Altered Inotropic Responsiveness and Gene Expression of Hypertrophied Myocardium With Captopril.
W. W. Brooks, O. H. L. Bing, M. O. Boluyt, A. Malhotra, J. P. Morgan, N. Satoh, W. S. Colucci, and C. H. Conrad (2000)
Hypertension 35, 1203-1209
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Science. ISSN 0036-8075 (print), 1095-9203 (online)