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Science 27 January 1978:
Vol. 199. no. 4327, pp. 436 - 437
DOI: 10.1126/science.619465
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Articles

Science, Vol 199, Issue 4327, 436-437
Copyright © 1978 by American Association for the Advancement of Science

articles

Pharmacologic effects in man of a specific serotonin-reuptake inhibitor

L Lemberger, H Rowe, R Carmichael, S Oldham, JS Horng, FP Bymaster, and DT Wong

Fluoxetine (Li-ly 110140) caused a 63 percent inhibition of [3H]serotonin uptake into platelets obtained from normal volunteers to whom the drug was administered daily for 7 days. This dose had no effect on the usual pressor response produced by injections of norepinephrine or tyramine.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Long-term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding.
S. Peroutka and S. Snyder (1980)
Science 210, 88-90
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Tricyclic antidepressants: long-term treatment increases responsivity of rat forebrain neurons to serotonin.
C de Montigny and G. Aghajanian (1978)
Science 202, 1303-1306
   Abstract »    PDF »


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