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Science 27 January 1978:
Vol. 199. no. 4327, pp. 431 - 432
DOI: 10.1126/science.619464
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Articles

Science, Vol 199, Issue 4327, 431-432
Copyright © 1978 by American Association for the Advancement of Science

articles

Ammonia intoxication in the near-adult cat as a result of a dietary deficiency of arginine

JG Morris and QR Rogers

Near-adult cats, fasted overnight, and given a single meal of a complete amino acid diet without arginine, developed hyperammonemia and showed clinical symptoms of ammonia toxicity within 2 hours. One cat (2.7 kilograms) died 4.5 hours after ingesting only 8 grams of the diet. Since ornithine also prevented hyperammonemia, it appears that the domestic cat cannot synthesize ornithine.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Nutritional Consequences of Interspecies Differences in Arginine and Lysine Metabolism.
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J. Nutr. 137, 1626S-1641S
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Inaugural Article: Comparative nutrition and metabolism: Explication of open questions with emphasis on protein and amino acids.
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PNAS 102, 17897-17902
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Excess Dietary Lysine Does Not Cause Lysine-Arginine Antagonism in Adult Cats.
A. J. Fascetti, D. J. Maggs, M. L. Kanchuk, H. E. Clarke, and Q. R. Rogers (2004)
J. Nutr. 134, 2042S-2045S
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Generation of a Mouse Model for Arginase II Deficiency by Targeted Disruption of the Arginase II Gene.
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Molecular Sites of Regulation of Expression of the Rat Cationic Amino Acid Transporter Gene.
K. S. Aulak, J. Liu, J. Wu, S. L. Hyatt, M. Puppi, S. J. Henning, and M. Hatzoglou (1996)
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Role of Arginine in Trauma, Sepsis, and Immunity.
S. J. Kirk and A. Barbul (1990)
JPEN J Parenter Enteral Nutr 14, 226S-229S
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Arginine: Biochemistry, Physiology, and Therapeutic Implications.
A. Barbul (1986)
JPEN J Parenter Enteral Nutr 10, 227-238
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