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Science 20 January 1978:
Vol. 199. no. 4326, pp. 313 - 315
DOI: 10.1126/science.339349
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Articles

Science, Vol 199, Issue 4326, 313-315
Copyright © 1978 by American Association for the Advancement of Science

articles

Brain endolases as specific markers of neuronal and glial cells

D Schmechel, PJ Marangos, AP Zis, M Brightman, and FK Goodwin

There are three distinct enolase isoenzymes in brain; neuron-specific enolase (NSE), formerly referred to as neuron-specific protein, which is specifically localized in neurons, a nonneuronal enolase (NNE), and a third hybrid form. Light microscopy with immunocytochemical techniques has permitted localization of non-neuronal enolase. The NNE is located in glial cells with no staining of endothelial cells or neurons. Thus, NSE and NNE can be used as specific metabolic markers for neurons and glial cells, respectively.


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