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Science 20 January 1978:
Vol. 199. no. 4326, pp. 301 - 303
DOI: 10.1126/science.619457
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Articles

Science, Vol 199, Issue 4326, 301-303
Copyright © 1978 by American Association for the Advancement of Science

articles

Spinal fluid differences in experimental allergic encephalomyelitis and multiple sclerosis

HS Gutstein and Cohen SR

The spinal fluid of sheep with experimental allergic encephalomyelitis contains myelin basic protein (6 to 18 nanograms per milliliter) bound to antibody as well as excess free antibody. This bound myelin basic protein appeared concurrently with the onset of the disease and remained elevated until death. In contrast, in active multiple sclerosis, the spinal fluid contains free myelin basic protein and there are no detectable levels of antibody. The results indicate that the antibodies enter the spinal fluid from the serum by passive diffusion. This mechanism may also explain the presence of viral antibodies in the spinal fluid of multiple sclerosis patients.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
CSF Antibody to Myelin Basic Protein: Measurement in Patients With Multiple Sclerosis and Subacute Sclerosing Panencephalitis.
H. S. Panitch, C. J. Hooper, and K. P. Johnson (1980)
Arch Neurol 37, 206-209
   Abstract »    PDF »
Measles and Vaccinia Antibodies in Multiple Sclerosis.
J. M. Adams (1978)
JAMA 240, 637
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)