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Science 20 January 1978:
Vol. 199. no. 4326, pp. 299 - 301
DOI: 10.1126/science.619456
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Articles

Science, Vol 199, Issue 4326, 299-301
Copyright © 1978 by American Association for the Advancement of Science

articles

Perfusion preservation of hearts for 6 to 9 days at room temperature

J Linask, J Votta, and M Willis

The combination of a defined medium with single-pass perfusion has made possible long-term maintenance of beating rat hearts at 22 degrees C in vitro. The 6- to 9-day survival period appears to be the longest so far reported for hearts. This method provides a stable system which should be useful for investigating the role of single factors in myocardial preservation and evaluating the effects of exposure to pharmacological and toxicological agents.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)